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by Dr Karine A.N. Macritchie
and Professor Allan H.
Published: July 2012
In the management of mania, pharmacological
treatment plays a key part in any comprehensive package of care.
The pharmacological management of mania is a skill essential to the
practice of acute general psychiatry.
Over recent years, new agents have joined the
armoury of anti-manic treatments and the evidence base for these
treatments is increasing. Updated guidelines for evidence-based
treatments for mania have been published; however, the management
of treatment-resistant mania remains challenging and is informed by
This module summarises current thinking on the
neural mechanisms of mania and the current view of best practice in
its pharmacological management, focusing particularly on recently
published guidelines from the British Association for
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